Preclinical Development for clevidipine

Pharmacokinetics & Toxicity Hypertension also referred to as high blood pressure is one of the leading causes of death in the world. The sudden surge of blood pressure damages organs such as the heart. According to the World Health Organization (WHO), hypertension is the second leading cause of fatalities in the world after Cancer. In the U.S, the chronic illness affects over 72 million people who are over 20 years of age. Clevidipine is a U.S drug used in the reduction of blood pressure in patients. The drug is highly effective in controlling acute cases of elevated blood pressure as compared to nitroglycerin and sodium nitroprusside as far as perioperative setting is concerned. Clevidipine is also very effective in patients suffering from acute hypertension. In fact, data shows that the drug is recommended for patients who can only ingest medication intravenously. This characteristic makes the clevidipine the recommended option for patients with hypertensive emergency cases and those undergoing cardiac surgery. This part of the essay shall delve into the use of clevidipine in animals and tissues as part of the pre-clinical development. In pre-clinical developments, major studies were conducted on rats and dogs, as well as limited studies on rabbits.

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